Correction to Importance of Purity Evaluation and the Potential of Quantitative 1H NMR as a Purity Assay
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چکیده
منابع مشابه
Importance of Purity Evaluation and the Potential of Quantitative 1H NMR as a Purity Assay
In any biomedical and chemical context, a truthful description of chemical constitution requires coverage of both structure and purity. This qualification affects all drug molecules, regardless of development stage (early discovery to approved drug) and source (natural product or synthetic). Purity assessment is particularly critical in discovery programs and whenever chemistry is linked with b...
متن کاملCorrection to Importance of Purity Evaluation and the Potential of Quantitative 1H NMR as a Purity Assay
Supporting Information SI‐1 The Importance of Purity Evaluation and the Potential of Quantitative 1H NMR as a Purity Assay Guido F. Pauli,1,2* Shao‐Nong Chen,1 Charlotte Simmler,1 David C. Lankin,1 Tanja Gödecke,1 Birgit U. Jaki,1,2 J. Brent Friesen,1,2,3 James B. McAlpine,1,2 and José G. Napolitano1,2 1Department of Medicinal Chemistry and Pharmacognosy and 2Institute for Tuberculosis Research...
متن کاملAbsolute Quantitative 1H NMR Spectroscopy for Compound Purity Determination
W e encourage our authors to consider the use of absolute quantitative 1 H NMR spectroscopy to determine the purity of biologically tested research compounds. The Perspective by Pauli et al. (DOI: 10.1021/jm500734a) in this issue provides an excellent overview of quantitative 1 H NMR spectroscopy methods and their use for purity determination. The major advantages of these techniques are that t...
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ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2015
ISSN: 0022-2623,1520-4804
DOI: 10.1021/acs.jmedchem.5b01667